2016 Cancer Frontier Fund Projects

Cancer Frontier Fund

The Cancer Frontier Fund was launched by The Foundation for Barnes-Jewish Hospital to realize the vision of Amy and Bill Koman to give every person the opportunity to help accelerate the pace of cancer breakthroughs.

Every award made from the Foundation’s Cancer Frontier Fund is given to support clinical research projects at the Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington Unviersity School of Medicine that are focused on rapidly advancing better treatments and prevention strategies for cancer.


2016 Research Projects Funded

Regulation of Glioblastoma Stem-Like Cells by CDC20-Anaphase-Promoting Complex
Principal investigator: Albert Kim, MD, PhD

Goal: To develop new treatments for brain cancer by better understanding the mechanisms that control cancer stem cells, which are resistant to conventional therapies and are responsible for cancer recurrence.

Deactivating the Innate Immune Defense Mechanism of Pancreatic Cancer
Principal investigator: Kian Lim, MD, PhD

Goal: To develop therapies to “deactivate” the defense mechanisms in pancreatic cancer cells that make them resistant to chemotherapy.

Exploring T Cell Diversity as a Novel Mechanism for Cancer Immunotherapy
Principal investigator: Ryan Teague, PhD

Goal: To acquire a deeper understating of how T cells possibly influence patient response to immunotherapy so the T cells can be harnessed to improve outcomes for patients with cancer.

Axonal Maintenance for Prevention of Chemotherapy-Induced Peripheral Neuropathy
Principal investigator: Jeff Milbrandt, MD, PhD

Goal: To slow or block the development of nerve damage, and its related numbness and pain in patients who have been treated with chemotherapy.

Tumor-Environment Communication Regulating Metastasis
Principal investigator: Greg Longmore, PhD

Goal: To better understand the way the area within and around a breast cancer tumor influences the spread of tumor cells to find more effective options to prevent and treat the spread of breast cancer.

Characterizing the Effects of Sexual Dimorphism on Glioma Metabolism
Principal investigator: Principal investigator: Joseph Ippolito, MD, PhD

Goal: To test a novel imaging technique to prove that the brain cancer glioblastoma multiforme (GBM) has a different metabolism in men than women that makes it more aggressive and more resistant to treatment. These research findings could lead to different imaging and treatments for men and women.

Siteman Cancer Center Breast Cancer SPORE
Principal investigator: Principal investigator: William Gillanders, MD

Goal: To create a Breast Specialized Program of Research Excellence (SPORE) program focused on tumor immunology, oncologic imaging, surgical oncology and breast cancer biology that will enable researchers to quickly translate basic science discoveries to clinical uses for patients with breast cancer.


For more information:

Contact Kris Marino at 314-286-0602 or KMarino@bjc.org