2016 Cancer Frontier Fund Projects – Coming Soon!
Cancer Frontier Fund
The Cancer Frontier Fund was launched by The Foundation for Barnes-Jewish Hospital to realize the vision of Amy and Bill Koman to give every person the opportunity to help accelerate the pace of cancer breakthroughs.
Every award made from the Foundation’s Cancer Frontier Fund is given to support clinical research projects at the Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington Unviersity School of Medicine that are focused on rapidly advancing better treatments and prevention strategies for cancer.
2015 Research Projects Funded
Project: Functional Genomics of Ovarian Cancer Metastasis
Principal investigator: Katherine Fuh, MD, PhD
Goal: Identify which cell mechanisms are responsible for the spread of ovarian cancer so these pathways can be targeted with new therapies.
Project: Designing Novel Therapeutic Approaches to Pancreatic Ductal Adenocarcinoma (PDAC)
Principal investigator: William Hawkins, MD
Goal: Advance four new potentially transformative treatments to improve survival for patients with pancreatic cancer.
Project: Assessment of Functional Status of Estrogen Receptors in Breast Cancer by PET
Principal investigator: Farrokh Dehdashti, MD
Goal: Determine if a non-invasive imaging test can provide specific information about the
functional status of estrogen receptors in breast cancer cells so patients can receive individualized treatment
based on the test results.
Project: FDOPA-PET/MRI for the Pre-operative Evaluation of Gliomas
Principal investigator: Jonathan McConathy, MD, PhD
Goal: Combine molecular and structural imaging techniques to better define brain tumor
borders, improve surgical outcomes and identify patients with aggressive brain tumors needing more urgent
Project: Immune-Based Therapies for AML
Principal investigator: John DiPersio, MD, PhD
Goal: Find new avenues to treat leukemia by activating the patient’s own immune cells.
Project: Mechanisms of Gastrointestinal Tumorigenesis
Principal investigator: Principal investigator: Jason C. Mills, MD, PhD
Goal: Identify which genes trigger pre-cancerous growths in the stomach and intestines and
find drugs targeting those genes to stop cancer before it starts.
Project: DNA Replication, Nuclear Architecture and Genome Stability
Principal investigator: Principal investigator: Dale Dorsett, PhD
Goal: Discover how cells repair, replicate and pass on their genomes after damage caused by
chemotherapy, in order to improve cancer therapy effectiveness and decrease chemotherapy side effects.
Project: Memory-Like Natural Killer (NK) Cells for Cancer Immunotherapy
Principal investigator: Principal investigator: Todd A. Fehniger, MD, PhD
Goal: Advance understanding of how natural killer (NK) cells work in order to harness their
power to develop immunotherapy-based cancer treatment.
Project: Targeting Focal Adhesion Kinase to Render Pancreatic Cancer Responsive to
Principal investigator: Principal investigator: David G. DeNardo, PhD
Goal: Develop a more effective way to treat pancreatic cancer by decreasing the ability of
cancer cells to build a protective barrier around tumors, and then targeting the cancer with
For more information:
Contact Kris Marino at 314-286-0602 or KMarino@bjc.org